You want to find the compatibility documents on the AVid website. They will have specific details about which computer and OS you can have run with which specific ProTools product.
For INstance, My Mbox2 coupled with my computer only goes to ProTools le 7.4, no higher.
I'm pretty much in the box these days, however I'm curious as to how bad the sync is with external MIDI boxes. I'd imagine it's repeatable, if not predictable, so a quick slide after tracking should get you back in time.
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